एंडॉर्फिन
(एंडोर्फिन या पानावरून पुनर्निर्देशित)
एंडॉर्फिन (एंडोजेनस मॉर्फिनपासून संश्लेषित) हे मेंदूमध्ये तयार होणारे पेप्टाइड्स संप्रेरक आहेत, जे वेदनांची तीव्रता अवरोधित करतात आणि निरोगीपणाची भावना वाढवतात.[१][२][३] ते मेंदूच्या पिट्यूटरी ग्रंथीमध्ये तयार होतात आणि साठवले जातात. एंडोर्फिन हे अंतर्जात वेदनाशामक आहेत जे बहुतेक वेळा शारीरिक व्यायाम किंवा संभोगादरम्यान मेंदू आणि अधिवृक्क मेडुलामध्ये तयार होतात आणि वेदना, स्नायूंचे पेटके (आखडणे) टाळतात आणि तणाव कमी करतात.[४][५][६][७]
संदर्भ
[संपादन]- ^ Stefano GB, Ptáček R, Kuželová H, Kream RM (1515). "Endogenous morphine: up-to-date review 2011" (PDF). Folia Biologica. 58 (2): 49–56. PMID 22578954.
Positive evolutionary pressure has apparently preserved the ability to synthesize chemically authentic morphine, albeit in homeopathic concentrations, throughout animal phyla. ... The apparently serendipitous finding of an opiate alkaloid-sensitive, opioid peptide-insensitive, µ3 opiate receptor subtype expressed by invertebrate immunocytes, human blood monocytes, macrophage cell lines, and human blood granulocytes provided compelling validating evidence for an autonomous role of endogenous morphine as a biologically important cellular signalling molecule (Stefano et al., 1993; Cruciani et al., 1994; Stefano and Scharrer, 1994; Makman et al., 1995). ... Human white blood cells have the ability to make and release morphine
- ^ "μ receptor". IUPHAR/BPS Guide to PHARMACOLOGY. International Union of Basic and Clinical Pharmacology. 15 March 2017. 28 December 2017 रोजी पाहिले.
Comments: β-Endorphin is the highest potency endogenous ligand ... Morphine occurs endogenously.
- ^ Poeaknapo C, Schmidt J, Brandsch M, Dräger B, Zenk MH (September 2004). "Endogenous formation of morphine in human cells". Proceedings of the National Academy of Sciences of the United States of America. 101 (39): 14091–14096. Bibcode:2004PNAS..10114091P. doi:10.1073/pnas.0405430101. PMC 521124. PMID 15383669.
- ^ Pilozzi A, Carro C, Huang X (December 2020). "Roles of β-Endorphin in Stress, Behavior, Neuroinflammation, and Brain Energy Metabolism". International Journal of Molecular Sciences. 22 (1): 338. doi:10.3390/ijms22010338. PMC 7796446 Check
|pmc=value (सहाय्य). PMID 33396962 Check|pmid=value (सहाय्य). - ^ Howlett TA, Tomlin S, Ngahfoong L, Rees LH, Bullen BA, Skrinar GS, McArthur JW (June 1984). "Release of beta endorphin and met-enkephalin during exercise in normal women: response to training". British Medical Journal. 288 (6435): 1950–1952. doi:10.1136/bmj.288.6435.1950. PMC 1442192. PMID 6329401.
- ^ Goldfarb AH, Jamurtas AZ (July 1997). "Beta-endorphin response to exercise. An update". Sports Medicine. 24 (1): 8–16. doi:10.2165/00007256-199724010-00002. PMID 9257407. S2CID 72824962.
- ^ "Endorphins: What They Are and How to Boost Them". Cleveland Clinic (इंग्रजी भाषेत). 2023-03-25 रोजी पाहिले.